IGF-1 LR3 -Insulin-like Growth Factor-1 -100 MCG / VIAL -5 VIALS
Description:
Insulin-like Growth Factor-1Dosage:
100 MCG / VIALQuantity:
5 VIALSWeight:
0.03470 KG
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- IGF-1 LR3 Receptor Grade is a premium research reagent for use in cell growth studies, IGF receptors and IGF binding proteins and is more potent than rH IGF1 and media grade IGF1. (Standard IGF1-LR3.)
What is IGF1-LR3?
- IGF1-LR3 is a modified version of insulin-like growth factor-1. The full name of the peptide is insulin-like growth factor-1 long arginine 3. All IGF-1 derivatives play prominent roles in cell division, cell proliferation, and cell-to-cell communication. Though it has similar effects, IGF-1 LR3 does not adhere to IGF binding proteins as strongly as IGF-1. This results in IGF1-LR3 remaining in the bloodstream 120 times longer than IGF-1. IGF1-LR3 gains its prolonged half-life as a result of its structural changes. The peptide is created by adding 13 amino acids to the N-terminal end of IGF-1 and by converting the glutamic acid at position 3 of IGF-1 to an arginine residue.
IGF1-LR3 Structure
- Sequence: MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA
- Molecular Formula: C400H625N111O115S9
- Molecular Weight: 9117.5 g/mol
- CAS Number: 946870-92-4
- Source: PubChem
IGF1-LR3 Research
Cell Divison
- IGF1-LR3 Research
- Cell Divison
- Like IGF-1, IGF1-LR3 is a potent stimulus for cell division and proliferation. Its primary effects are on connective tissues like muscle and bone, but it also promotes cell division in liver, kidney, nerve, skin, lung, and blood tissues. IGF-1 is best thought of as a maturation hormone because it not only promotes cell proliferation, but differentiation as well. IGF-1 causes cells to mature, in other words, so that they can carry out their specialized functions.
- Unlike IGF-1, IGF1-LR3 remains in the bloodstream for long periods of time. This property makes IGF1-LR3 a much more potent molecule. A dose of IGF1-LR3 provides approximately three times as much cell activation as a similar dose of IGF-1. Note that IGF1-LR3 and all IGF-1 derivatives do not promote cell enlargement (hypertrophy), but rather promote cell division and proliferation (hyperplasia). In the case of muscle, for instance, IGF1-LR3 does not cause muscle cells to get larger, but it does increase total numbers of muscle cells.
- Fat Metabolism and Diabetes
- IGF1-LR3 boosts fat metabolism in an indirect manner by binding to both the IGF-1R receptor and the insulin receptor. These actions increase glucose uptake from the blood by muscle, nerve, and liver cells. This results in an overall decrease in blood sugar levels, which then triggers adipose tissue as well as the liver to begin breaking down glycogen and triglycerides. Overall, this produces a net decrease in adipose tissue and a net energy consumption (i.e. net catabolism).
- Given its role in reducing blood sugar levels, it should come as no surprise that IGF1-LR3 reduces insulin levels as well as the need for exogenous insulin in diabetes. In most cases, this translates into a 10% decrease in insulin requirements to maintain the same blood sugar levels. This fact may help scientists understand how to decrease insulin doses in individuals who have decreased insulin sensitivity and may even offer insight into preventing type 2 diabetes in the first place.
- Impairs Myostatin
- Myostatin (a.k.a. growth differentiation factor 8) is a muscle protein that primarily inhibits the growth and differentiation of muscle cells. While this function is important to prevent unregulated hypertrophy and ensure proper healing following injury, there are times when inhibiting myostatin could be of benefit. The ability to stop myostatin from functioning could be useful in conditions like Duchenne muscle dystrophy (DMD) or in people who suffer muscle loss during prolonged immobility. In these cases, inhibiting this natural enzyme could help to slow muscle breakdown, maintain strength, and stave off morbidity.
- , it has been found that IGF1-LR3 and other IGF-1 derivatives are capable of counteracting the negative effects of myostatin to protect muscle cells and prevent apoptosis. IGF1-LR3, thanks to its long half-life, is highly effective in counteracting myostatin and appears to work by activating a muscle protein called MyoD[1], [2]. MyoD is the protein normally activated by exercise (e.g. weight lifting) or tissue damage and is responsible for muscle hypertrophy.
- Increased amino acid transport to cells
- Increased glucose transport
- Increased protein synthesis
- Decreased protein degradation
- Increased RNA synthesis
- IGF1-LR3 Longevity Research
- IGF1-LR3 promotes tissue repair and maintenance throughout the body, making it a protective molecule against cell damage and the effects of aging. Research in cows and pigs indicates that IGF1-LR3 administration may be an effective solution for offsetting the effects of cellular aging. Ongoing research in mice seeks to determine if IGF1-LR3 might be useful in preventing progression of a wide range of conditions such as dementia, muscle atrophy, and kidney disease.
- Lifespan of male and female mice is correlated with IGF-1 levels.
- Source: ResearchGat
- IGF1-LR3 exhibits minimal to moderate side effects, low oral and excellent subcutaneous bioavailability
- Glucocorticoids, secreted primarily by the adrenal glands, are important clinical drugs used to control pain and reduce inflammation in autoimmune diseases, neurological injury, cancer, and more. Unfortunately, glucocorticoids have a number of undesirable side effects such as muscle wasting, fat gain, and deterioration of bone density. There is some interest in using IGF1-LR3 to reduce the side effects of glucocorticoids and thus allow for more effective therapy[6].
- IGF1-LR3 exhibits minimal to moderate side effects, low oral and excellent subcutaneous bioavailability
- Regular IGF-1 only has a half-life of about 10-20 minutes if the human body and is quickly destroyed. The most effective Igf analog form of all is IGF-1 L[R3]. Because of its chemical alteration and the amino acid changes, IGF-1 L[R3] can avoid binding to proteins in the human body and so to have a much longer half life, around 20-30 hours.
Adverse reaction
- This list presents the most serious and/or most frequently observed adverse reactions using IGF-1 or its analogs:
- Users can feel drained and tired all day.
- IGF-1 may cause your hands, fingers and knuckles to ache.
- IGF-1 L[R3] used in larget quantity around the 100mcgrange may cause headaches, occasional nausea and can contribute to low blood sugar or hypoglycaemia.
Instructions for reconstitution
- The injection is given into the sub-cutaneous layer which includes adipose tissue (fat).
- If you are using insulin syringes which have short needles, you will need to enter the skin at 90°. to the skin, otherwise you can inject as shown in the illustration above with a 29 or 30 gauge, 0.5" needle.
Dosage
- Reommended dosage of IGF-1 L[R3]: 50-80 mcg per day.
Storage
- This product can be used not more than 3 years from the production date (see box).
- After reconstitution, may be stored for a maximum of 14 days in a refrigirator at 2°C – 8°C.
- Store vials in an upright position.
- Store in a refrigerator (2°C – 8°C). Keep in the outer carton in order to protect from light.
- For one month can be stored at room temperature.
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